The goal of the proposed research is to develop an efficient asymmetric synthesis of salicylihalamide A, a novel antitumor agent. Salicylihalamide A has been shown to have extraordinary activity against a variety of human solid tumor cell lines (mean GI50 approximately 15 x 10-9 M in the National Cancer Institutes 60 tumor cell line panel). Intriguingly, salicylihalamide A did not exhibit any significant correlation to the profiles of known antitumor compounds in the National Cancer Institute's standard agent database. This suggests that salicylihalamide A may have a unique mechanism of cellular tumor inhibition. The potential for development of a new class of chemotherapeutic agents and the paucity of material available from the natural source make salicylihalamide A an attractive target for synthesis. The proposed synthesis will make available sufficient quantities of the natural product for biological testing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32CA081704-01
Application #
2861923
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Lohrey, Nancy
Project Start
1999-11-19
Project End
Budget Start
1999-06-16
Budget End
2000-06-15
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065