The purpose of this proposal is to further understanding of the prevalence, characteristics and predictors of the psychosocial health status, health risk behaviors and neurological sequelae of long-term survivors of childhood cancer. The research proposed in this application will make use of the Childhood Cancer Survivor Study, a multi-institutional collaborative project that has established and followed a retrospectively-ascertained cohort of long-term survivors of childhood cancer and 6,000 sibling controls. This is the largest sample of well-characterized childhood cancer survivors and sibling controls known to date. Previous work suggests that certain subsets of childhood cancer survivors are vulnerable to a variety of physical and psychosocial problems, but the generalizability of these findings are limited by small sample sizes, data derived from single institutions, and lack of a control group. Furthermore, study in this field has yet to identify critical variables that influence (1) long-term survivors' psychosocial problems, but the generalizability of these findings are limited by small sample sizes, data derived from single institutions, and lack of a control group. Furthermore, study in this field has yet to identify critical variables that influence (1) long-term survivors' psychosocial status/quality of life, including their experiences with pain, and (2) behaviors that place them at risk for future health problems. The work to be conducted during the period of this functioning, and health behaviors. Physical, psychological, social and neurological factors that potentially influence these outcomes will be investigated. Specific hypotheses related to these outcomes are proposed and potentially moderating and mediating factors will be investigated. Psychosocial support interventions throughout a continuum of care- from diagnosis through treatment and into long-term survivorship-will be suggested. Plans for intervention research will be forthcoming.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA089875-02
Application #
6514899
Study Section
Special Emphasis Panel (ZRG1-RPHB-3 (01))
Program Officer
Lohrey, Nancy
Project Start
2002-02-08
Project End
Budget Start
2002-02-08
Budget End
2003-02-07
Support Year
2
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost
Name
University of California Los Angeles
Department
Pediatrics
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Zebrack, Brad J; Yi, Jaehee; Petersen, Laura et al. (2008) The impact of cancer and quality of life for long-term survivors. Psychooncology 17:891-900
Casillas, Jacqueline N; Zebrack, Brad J; Zeltzer, Lonnie K (2006) Health-related quality of life for Latino survivors of childhood cancer. J Psychosoc Oncol 24:125-45
Zebrack, Brad J; Eshelman, Debra A; Hudson, Melissa M et al. (2004) Health care for childhood cancer survivors: insights and perspectives from a Delphi panel of young adult survivors of childhood cancer.. Cancer 100:843-50
Zebrack, Brad J; Casillas, Jacqueline; Nohr, Lindsay et al. (2004) Fertility issues for young adult survivors of childhood cancer. Psychooncology 13:689-99
Zebrack, Brad J; Gurney, James G; Oeffinger, Kevin et al. (2004) Psychological outcomes in long-term survivors of childhood brain cancer: a report from the childhood cancer survivor study. J Clin Oncol 22:999-1006
Zebrack, Brad J; Zeltzer, Lonnie K; Whitton, John et al. (2002) Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin's disease, and non-Hodgkin's lymphoma: a report from the Childhood Cancer Survivor Study. Pediatrics 110:42-52