Tetrazomine is a biologically active natural product, which has shown potent cytotoxicity activity against P388 leukemia cells in vivo and good antimicrobial activity against both Gram-negative and Gram-positive bacteria. Therefore, this compound is an exciting lead for development as a potential chemotherapeutic agent. This proposal describes an investigation of tetrazomine through total synthesis and the exploration of structure-activity relationships through analogue generation. The proposed synthesis offers many advantages such as synthetic brevity in addition to potentially high-yielding reactions. These advantages coupled with the potential for molecular modification to probe structure-activity relationships, leads to a novel and useful route to study this very interesting molecule.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32CA103341-02
Application #
6815071
Study Section
Special Emphasis Panel (ZRG1-F04 (20))
Program Officer
Lohrey, Nancy
Project Start
2003-09-29
Project End
2005-09-28
Budget Start
2004-09-29
Budget End
2005-09-28
Support Year
2
Fiscal Year
2004
Total Cost
$42,976
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138