Proton magnetic resonance spectroscopic imaging has been demonstrated to have significant clinical potential for the noninvasive localization brain tumors. In vivo spectroscopic measurements have revealed changes in brain metabolites that can be used to classify tissues as healthy or cancerous. However, it has been shown that radiation therapy changes the metabolite levels in healthy tissue, thus making it more difficult to distinguish between healthy tissue and tumor using spectroscopy alone. To overcome this problem, this research will study the integration of spectroscopy with diffusion and perfusion imaging into an automated tissue classification system. The time- and dose-response of radiation-induced changes in healthy brain tissue will be assessed by analyzing serial spectroscopic, diffusion, and perfusion imaging data from patients undergoing radiation therapy. The abnormality of a given volume of tissue will then be defined as the difference between the measured and expected values for a given parameter. An overall abnormality index will then be computed from a combination of spectroscopic, diffusion, and imaging parameters. It is hypothesized that this will improve the accuracy in identifying tumor in post-radiotherapy examinations compared with conventional imaging or MRSI alone. This will allow clinicians and researchers to better understand patterns of failure following radiotherapy of high grade gliomas, and adjust accordingly.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32CA105944-01A1
Application #
6884244
Study Section
Special Emphasis Panel (ZRG1-F01 (20))
Program Officer
Lohrey, Nancy
Project Start
2005-04-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
1
Fiscal Year
2005
Total Cost
$48,296
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143