The acute behavioral effects of cocaine are mediated, in part, by monoamine transmitters located in mesolimbic circuits. The presence of high concentrations of the serotonin (5HT) receptor subtypes, 5HT4 and 5HT6, in the nucleus accumbens and striatum suggests that 5HT systems may modulate the locomotor and discriminative stimulus properties of cocaine. The intent of the present studies is to assess this hypothesis by measuring the locomotor and discriminative stimulus effects of cocaine following either activation or blockade of the brain 5HT4 receptor with systemic administration of 5HT4 receptor ligands as well as following depletion of the brain 5HT6 receptor with intracranial infusion of specific antisense oligonucleotides.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DA005879-02
Application #
6155125
Study Section
Special Emphasis Panel (ZDA1-MXS-M (01))
Program Officer
Pilotte, Nancy S
Project Start
1999-09-25
Project End
Budget Start
1999-09-25
Budget End
2000-06-30
Support Year
2
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555