Cocaine remains a challenging synthetic target since few enantioselective methods for its construction exist. This proposal seeks to extend the scope of the 2-azaallyl anion cycloaddition methodology to the asymmetric synthesis of cocaine through the development of a novel cyclic 2-azaallyl anion. A significant advantage of the proposed route is that it is readily adaptable for the generation of novel cocaine analogs, including 6- and 7-substituted analogs and analogs with bridgehead substituents. The pharmacological profile of these analogs will be assessed by the Cocaine Treatment and Discovery Program, with the aim toward identifying analogs with cocaine antagonist activity. Such analogs may have potential use as medications for the treatment of cocaine abuse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DA005954-02
Application #
6378447
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Biswas, Jamie
Project Start
2001-04-01
Project End
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
2
Fiscal Year
2001
Total Cost
$34,832
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109