A substantial amount of evidence suggests that 5-HT2A receptors mediate many of the behavioral effects of the hallucinogen LSD. This conclusion is based largely on the results of pharmacological studies which utilized compounds that lacked the ability to differentiate between the 5-HT2A and other members of the 5-HT2 family (5-HT2B, 5-HT2C) as well as other families of 5-HT receptors. However, a limited number of recent assessments of this question suggest that some aspects of LSD-invoked behavior may be mediated by 5-HT2C receptors as well. The intent of the present proposal is to directly assess the relative roles of 5-HT2A and 5HT2C receptors in the locomotor and discriminative stimulus effects of LSD employing selective 5-HT2A or 5-HT2C receptor ligands. In addition, we will map the anatomical circuitry upon which the behavioral effects of LSD are dependent using strategies that incorporate both immediate early gene expression in rat brain and direct site-specific microinfusion technologies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DA006057-03
Application #
6592785
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2001-06-01
Project End
Budget Start
2002-06-01
Budget End
2003-06-23
Support Year
3
Fiscal Year
2002
Total Cost
$46,192
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555