The enzyme fatty acid amide hydrolase (FAAH) plays an important role in a variety of pathophysiological conditions of mammalian nervous system. It is been identified that a human natural variant of FAAH P129T) is associated with drug abuse and dependence. We have shown that P129T mutant enzyme has wild type FAAH catalytic properties, but is more susceptible to proteolysis in vitro. In this proposal, I will determine the structure of P129T-FAAH using x-ray crystallography. With the aid of structural information, I will further investigate the molecular basis for functional alterations of P129T-FAAH. Findings from these studies will guide the development of potential therapeutics for drug addiction.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DA018461-03
Application #
7127175
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2004-09-01
Project End
2007-05-18
Budget Start
2006-09-01
Budget End
2007-05-18
Support Year
3
Fiscal Year
2006
Total Cost
$36,954
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037