Drugs of abuse have been shown to exert long lasting neuroadaptive changes in regions of the mesolimbic dopamine system. These include changes in transcriptional regulation, neuronal morphology, and electrophysiological properties of the neurons. Although many reports have implicated these neuroplastic changes in the behavioral manifestation of sensitization and reward tolerance, fewer studies have examined the connection between intracellular signaling molecules, neuronal morphology and connectivity, and cocaine responsiveness. Nuclear Factor Kappa B (NFKB), a transcription factor induced by inflammation and immune responses, regulates cell survival and neural plasticity and may be an important factor in the long term neuroadaptive changes associated with drug use. Our preliminary data support this hypothesis.
The aim of the current proposal is to understand the functional role of NFKB in changes associated with chronic cocaine administration at the behavioral and cellular levels.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DA019727-01
Application #
6936098
Study Section
Human Development Research Subcommittee (NIDA)
Program Officer
Babecki, Beth
Project Start
2005-06-01
Project End
2008-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
1
Fiscal Year
2005
Total Cost
$48,296
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Russo, Scott J; Dietz, David M; Dumitriu, Dani et al. (2010) The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci 33:267-76