Abstract

The overall goal of this project is to measure and quantitatively characterize the response of neurons in the inferior colliculus (IC) to acoustic stimuli.
The specific aims of this project are to characterize the non-linear, spectro- temporal and adaptive behaviors of single units in the central nucleus of the inferior colliculus using custom designed stimuli for this purpose. The inferior colliculus is a central way-station in the auditory system which plays a major role in the processing of complex sounds, such as speech. Characterizing these behaviors will allow one to better understand and predict how the mammalian IC processes complex sounds and ultimately to contribute a better understanding of the pathologies in speech recognition and language acquisition.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DC000354-01A1
Application #
2863398
Study Section
Special Emphasis Panel (ZRG1-IFCN-6 (01))
Program Officer
Sklare, Dan
Project Start
1999-09-01
Project End
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Seymour, Michelle L; Rajagopalan, Lavanya; Duret, Guillaume et al. (2016) Membrane prestin expression correlates with the magnitude of prestin-associated charge movement. Hear Res 339:50-9
Cai, Tiantian; Seymour, Michelle L; Zhang, Hongyuan et al. (2013) Conditional deletion of Atoh1 reveals distinct critical periods for survival and function of hair cells in the organ of Corti. J Neurosci 33:10110-22
Nilsen, Natalie; Brownell, William E; Sun, Sean X et al. (2012) Effect of membrane mechanics on charge transfer by the membrane protein prestin. Biomech Model Mechanobiol 11:107-18
McGuire, Ryan M; Liu, Haiying; Pereira, Fred A et al. (2010) Cysteine mutagenesis reveals transmembrane residues associated with charge translocation in prestin. J Biol Chem 285:3103-13
Brownell, William E (2009) WITHDRAWN: Membrane-based amplification in hearing. Hear Res :
Sachs, F; Brownell, W E; Petrov, A G (2009) Membrane Electromechanics in Biology, with a Focus on Hearing. MRS Bull 34:665
Minor, Jacob S; Tang, Hsiao-Yuan; Pereira, Fred A et al. (2009) DNA sequence analysis of SLC26A5, encoding prestin, in a patient-control cohort: identification of fourteen novel DNA sequence variations. PLoS One 4:e5762
Sun, Sean X; Farrell, Brenda; Chana, Matthew S et al. (2009) Voltage and frequency dependence of prestin-associated charge transfer. J Theor Biol 260:137-44