Our long term goal is to develop an effective training regime for auditory-based learning disabilities. The goal of the proposed study is to further understand the role of brainstem timing in auditory processing and literacy. Specifically, we are interested in the functional relations between brainstem and cortical processing, auditory processing and literacy in children with reading disability. We will characterize the auditory processing profile of children with reading disability and abnormal brainstem timing. Consequently, a perceptual training paradigm will be used to test the hypothesis that brainstem timing can be improved. We will also test the hypothesis that such training will generalize to speech perception and literacy related skills. Auditory evoked potentials and behavioral performance will be measured before and after behavioral training and compared between reading disabled children with normal and abnormal brainstem timing and normal learning children. We expect that training will result in changes in both cortical and brainstem function as well as in behavioral measures relating to brainstem timing. This study will thus result in better understanding of the physiological basis of learning disability and of the organization of the auditory system. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DC008052-01A1
Application #
7114160
Study Section
Communication Disorders Review Committee (CDRC)
Program Officer
Sklare, Dan
Project Start
2006-02-01
Project End
2009-01-31
Budget Start
2006-02-01
Budget End
2007-01-31
Support Year
1
Fiscal Year
2006
Total Cost
$45,976
Indirect Cost
Name
Northwestern University at Chicago
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Song, Judy H; Skoe, Erika; Banai, Karen et al. (2012) Training to improve hearing speech in noise: biological mechanisms. Cereb Cortex 22:1180-90
Song, Judy H; Skoe, Erika; Banai, Karen et al. (2011) Perception of speech in noise: neural correlates. J Cogn Neurosci 23:2268-79
Skoe, Erika; Nicol, Trent; Kraus, Nina (2011) Cross-phaseogram: objective neural index of speech sound differentiation. J Neurosci Methods 196:308-17
Banai, Karen; Sabin, Andrew T; Wright, Beverly A (2011) Separable developmental trajectories for the abilities to detect auditory amplitude and frequency modulation. Hear Res 280:219-27
Song, Judy H; Nicol, Trent; Kraus, Nina (2011) Test-retest reliability of the speech-evoked auditory brainstem response. Clin Neurophysiol 122:346-55
Chandrasekaran, Bharath; Kraus, Nina (2010) The scalp-recorded brainstem response to speech: neural origins and plasticity. Psychophysiology 47:236-46
Skoe, Erika; Kraus, Nina (2010) Auditory brain stem response to complex sounds: a tutorial. Ear Hear 31:302-24
Krizman, Jennifer L; Skoe, Erika; Kraus, Nina (2010) Stimulus rate and subcortical auditory processing of speech. Audiol Neurootol 15:332-42
Skoe, Erika; Kraus, Nina (2010) Hearing it again and again: on-line subcortical plasticity in humans. PLoS One 5:e13645
Banai, K; Ortiz, J A; Oppenheimer, J D et al. (2010) Learning two things at once: differential constraints on the acquisition and consolidation of perceptual learning. Neuroscience 165:436-44

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