Structure/Function of Heme Regulated Eif-2alpha Kinase

Rafie-Kolpin, Maryam

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 1F32DK009773-01
• Application #: 2640892
• Study Section: Medical Biochemistry Study Section (MEDB)
• Program Officer: Bishop, Terry Rogers
• Project Start: 1998-10-02
• Budget Start: 1998-06-01
• Budget End: 1999-05-31
• Support Year: 1
• Fiscal Year: 1998

Institution

• Name: Massachusetts Institute of Technology
• Type: Organized Research Units
• City: Cambridge
• State: MA
• Country: United States
• Zip Code: 02139

Publications

Rafie-Kolpin, Maryam; Han, An-Ping; Chen, Jane-Jane (2003) Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI. Biochemistry 42:6536-44

Bauer, B N; Rafie-Kolpin, M; Lu, L et al. (2001) Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase. Biochemistry 40:11543-51

Rafie-Kolpin, M; Chefalo, P J; Hussain, Z et al. (2000) Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion. J Biol Chem 275:5171-8