Abstract

In this work, I propose to characterize two isoforms of the nuclear receptor corepressor SMRT with respect to their ability to interact with various nuclear hormone receptors and their ability to effect transcriptional repression. I will also analyze the expression of these isoforms in different tissue to determine if expression of these isoforms are regulated and to potentially gain insight into the physiological roles these isoforms may play. In addition, I will develop an algorithm, which will use data from the EST database to identify other splicing isoforms of SMRT.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32DK062654-01
Application #
6552550
Study Section
Special Emphasis Panel (ZRG1-F06 (20))
Program Officer
Hyde, James F
Project Start
2003-04-01
Project End
Budget Start
2003-01-01
Budget End
2003-12-31
Support Year
1
Fiscal Year
2002
Total Cost
$44,212
Indirect Cost

  Institution

Name
University of California Davis
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Goodson, Michael L; Farboud, Behnom; Privalsky, Martin L (2007) An improved high throughput protein-protein interaction assay for nuclear hormone receptors. Nucl Recept Signal 5:e002
Goodson, Michael L; Jonas, Brian A; Privalsky, Martin L (2005) Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors. J Biol Chem 280:7493-503