Obesity is a major public health problem affecting 22% of adults in the United States. Despite public health efforts to combat obesity, it continues to increase in incidence along with obesity-related health costs. Obesity increases susceptibility for cardiovascular disease and non-insulin dependent diabetes, and has been associated with depression and anxiety. Chronic stress plays a role in the development of obesity, and has also been linked with depression and anxiety disorders. Moreover, obese individuals often have disruptions in the activity of the stress-responsive hypothalamic-pituitary-adrenal (HPA) axis. Thus, the literature supports strong links between stress, stress-related illnesses and the dysregulation of body weight. To determine the nature of the interactions between chronic stress and obesity, this proposal will use a rat model of high fat diet-induced obesity (DIO) combined with chronic variable stress (CVS) exposure to address three principal hypotheses: (1) chronic stress potentiates obesity in rats consuming high fat diet; (2) chronic stress responses are potentiated by short term consumption of high fat diet; and (3) chronic stress responses are attenuated by obesity induced by long term consumption of high fat diet.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK067820-02
Application #
6899772
Study Section
Special Emphasis Panel (ZRG1-F02A (20))
Program Officer
Podskalny, Judith M,
Project Start
2004-05-01
Project End
2005-10-31
Budget Start
2005-05-01
Budget End
2005-10-31
Support Year
2
Fiscal Year
2005
Total Cost
$24,148
Indirect Cost
Name
University of Cincinnati
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
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