The development of a replacement liver for transplant or as an extracorporeal support device is necessary to address the growing liver transplant waiting list and the limited number of available organs. Development of a tissue engineered liver is an exciting possible solution. Integration of hepatocytes and a bile duct system in a three dimensional scaffold where the natural bile canaliculi connect to a bile duct network to support bile flow has not been developed. This research will utilize a novel tissue engineering scaffold with a vascularized three dimensional scaffold structure with compartments for hepatic parenchyma and a biliary system that has been developed. With this scaffold, the factors regulating biliary epithelial cell growth and the mechanism of integration of a bile ducts and bile canaliculi will be identified. The effect of geometry, scaffold materials and growth factors will be studied. This scaffold for a tissue engineered liver will be tested in in-vitro and in-vivo models utilizing mature hepatocytes, small cell hepatocytes, biliary epithelial cells and non-parenchymal cells as cell sources. ? ? ?
| Hoganson, David M; Finkelstein, Eric B; Owens, Gwen E et al. (2016) A bilayer small diameter in vitro vascular model for evaluation of drug induced vascular injury. Biomicrofluidics 10:054116 |
| Hoganson, David M; Owens, Gwen E; Meppelink, Amanda M et al. (2016) Decellularized extracellular matrix microparticles as a vehicle for cellular delivery in a model of anastomosis healing. J Biomed Mater Res A 104:1728-35 |
| Lo, Justin H; Bassett, Erik K; Penson, Elliot J N et al. (2015) Gas Transfer in Cellularized Collagen-Membrane Gas Exchange Devices. Tissue Eng Part A 21:2147-55 |
| Hoganson, David M; Bassett, Erik K; Vacanti, Joseph P (2014) Lung tissue engineering. Front Biosci (Landmark Ed) 19:1227-39 |
| Hoganson, David M; Pryor 2nd, Howard I; Bassett, Erik K et al. (2011) Lung assist device technology with physiologic blood flow developed on a tissue engineered scaffold platform. Lab Chip 11:700-7 |
| Bassett, Erik K; Hoganson, David M; Lo, Justin H et al. (2011) Influence of vascular network design on gas transfer in lung assist device technology. ASAIO J 57:533-8 |
| Hoganson, David M; Pryor 2nd, Howard I; Spool, Ira D et al. (2010) Principles of biomimetic vascular network design applied to a tissue-engineered liver scaffold. Tissue Eng Part A 16:1469-77 |
| Hoganson, David M; O'Doherty, Elisabeth M; Owens, Gwen E et al. (2010) The retention of extracellular matrix proteins and angiogenic and mitogenic cytokines in a decellularized porcine dermis. Biomaterials 31:6730-7 |
| Hoganson, David M; Anderson, Jennifer L; Weinberg, Eli F et al. (2010) Branched vascular network architecture: a new approach to lung assist device technology. J Thorac Cardiovasc Surg 140:990-5 |
| Hoganson, David M; Owens, Gwen E; O'Doherty, Elisabeth M et al. (2010) Preserved extracellular matrix components and retained biological activity in decellularized porcine mesothelium. Biomaterials 31:6934-40 |
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