Patients with end stage renal disease (ESRD) constitute a small percentage of Medicare beneficiaries but account for a disproportionate amount of the money spent on Medicare. They are rehospitalized far more frequently than other persons, with 36% of patients rehospitalized within 30 days. As the Centers for Medicare and Medicaid Services (CMS) have increasingly focused on reducing 30-day hospital readmission rates in all Medicare patients including those on dialysis, they have started penalizing hospitals for 30-day readmissions. Even though physicians are increasingly incentivized to avoid 30-day rehospitalizations, it is not known if they are preventable in patients on dialysis (or in Medicare patients as a whole) or if some rehospitalizations are potentially beneficial. The causes of 30-day readmissions in patients on dialysis have not been previously described, and to date, no one has attempted to see if some 30-day rehospitalizations might prevent future adverse events in patients.
The First Aim i s mostly descriptive and will identify the most common hospitalization and rehospitalization pairs of diagnoses. It will also identify diagnosis pairs that are clinically related to each other and those that are not.
The Second Aim will take the most common causes of 30-day rehospitalization and identify groups of patients who are likely to be rehospitalized and those who are likely to die within 3 years, in order to risk-stratify patients b mortality and likelihood for rehospitalization.
The Third Aim will take patients who are at high likelihood for death and identify groups of patients who may potentially benefit from 30-day readmission by seeing if they have better outcomes than expected. This research will help clinicians and policy makers better understand when 30-day rehospitalizations may be beneficial to patients on dialysis. It will help direct policy makers to introduce policies that taget reductions in inappropriate rehospitalizations and will help physicians understand when to consider rehospitalization as a potential therapeutic treatment.

Public Health Relevance

Patients on dialysis are often readmitted to the hospital 30 days after discharge, and policy makers have started to financially penalize hospitals for these 30-day readmissions. Our proposed research will investigate the causes for these readmissions and determine if patients have a higher rate of death after a 30-day rehospitalization. We will also determine if some 30-day readmissions are beneficial to patients, or if all rehospitalizations are, in fact, detrimental to patients' health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32DK107123-03
Application #
9318518
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Rankin, Tracy L
Project Start
2015-07-20
Project End
2018-06-30
Budget Start
2017-07-20
Budget End
2018-06-30
Support Year
3
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304
Berns, Jeffrey S; Saffer, Tonya L; Lin, Eugene (2018) Addressing Financial Disincentives to Improve CKD Care. J Am Soc Nephrol 29:2610-2612
Kurella Tamura, Manjula; O'Hare, Ann M; Lin, Eugene et al. (2018) Palliative Care Disincentives in CKD: Changing Policy to Improve CKD Care. Am J Kidney Dis 71:866-873
Lin, Eugene; Chertow, Glenn M; Yan, Brandon et al. (2018) Cost-effectiveness of multidisciplinary care in mild to moderate chronic kidney disease in the United States: A modeling study. PLoS Med 15:e1002532
Lin, Eugene; Kurella Tamura, Manjula; Montez-Rath, Maria E et al. (2017) Re-evaluation of re-hospitalization and rehabilitation in renal research. Hemodial Int 21:422-429
Lin, Eugene; MaCurdy, Thomas; Bhattacharya, Jay (2017) The Medicare Access and CHIP Reauthorization Act: Implications for Nephrology. J Am Soc Nephrol 28:2590-2596
Lin, Eugene; Cheng, Xingxing S; Chin, Kuo-Kai et al. (2017) Home Dialysis in the Prospective Payment System Era. J Am Soc Nephrol 28:2993-3004