Optical coherence tomography has superior depth penetration, comparable spatial resolution, and superior temporal resolution than any other optical imaging technique, however it lacks the ability to utilize molecular contrast that other optical imaging modalities possess. Molecular contrast provides these techniques with the ability to enhance the contrast of particular tissue morphologies by the administration of contrast agents. It also enables them to record the time evolution of contrast agent concentration, a property extremely useful for drug development and discovery, developmental biology, and clinical diagnostics. We intend to couple proven nonlinear spectroscopic techniques to optical coherence tomography, in order to provide molecular contrast.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32EB004237-02
Application #
6951079
Study Section
Special Emphasis Panel (ZRG1-F05 (20))
Program Officer
Khachaturian, Henry
Project Start
2004-09-01
Project End
2006-08-31
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
2
Fiscal Year
2005
Total Cost
$50,548
Indirect Cost
Name
Duke University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Applegate, Brian E; Izatt, Joseph A (2006) Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Express 14:9142-55
Sarunic, Marinko V; Applegate, Brian E; Izatt, Joseph A (2006) Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. Opt Lett 31:2426-8
Sarunic, Marinko V; Applegate, Brian E; Izatt, Joseph A (2005) Spectral domain second-harmonic optical coherence tomography. Opt Lett 30:2391-3
Applegate, Brian; Yang, Changhuei; Izatt, Joseph (2005) Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques. Opt Express 13:8146-63
Applegate, Brian E; Yang, Changhuei; Rollins, Andrew M et al. (2004) Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Opt Lett 29:2252-4