Current brain machine interface (BMI) systems have shown success in providing relief for some central nervous system (CNS) disorders caused by disease or trauma. Unfortunately, widespread utility has been hampered by challenges associated with the configuration of non-invasive external receivers intended to detect in vivo electrical signals. The alternative is an implantable neuronal prosthetic capable of CNS integration allowing direct detection and bi-directional signaling. Unfortunately, these devices elicit chronic immune responses mainly due to their materials of construction which directly lead to decreased functionality and device failure. We have developed a novel material, cubic silicon carbide (3C-SiC), that meets all the requirements of an implantable neuronal prosthetic device and addresses the major problems of biocompatibility and passive electric properties.
The specific aims of the application have been designed to rigorously evaluate the biocompatibility of this and other semi-conductor materials in vivo longitudinally, determine the ability of a neuronal activation device constructed of 3C-SiC to elicit excitation and plasticity of organotypic hippocampal slice cultures and generate an implantable electrode device capable of bi-directional communication in vivo. In conjunction with the experimental aims, the applicant will advance his interdisciplinary knowledge, concentrating on disciplines applicable with relating technology to neuroscience, and further develop scientific writing and presentation skills.

Public Health Relevance

This application proposes to study the interaction between the central nervous system and a novel neuronal prosthetic developed by the applicant. This novel device has the potential to improve the lives of people suffering from many neurological disorders, such as amyotrophic lateral sclerosis (ALS), trauma resultant from stroke or acute injury, or be to used as an interface to control mechanized artificial limbs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32EB011884-01A1
Application #
8061410
Study Section
Special Emphasis Panel (ZRG1-F14-C (20))
Program Officer
Erim, Zeynep
Project Start
2010-09-30
Project End
2012-09-29
Budget Start
2010-09-30
Budget End
2011-09-29
Support Year
1
Fiscal Year
2010
Total Cost
$50,306
Indirect Cost
Name
University of South Florida
Department
Physiology
Type
Schools of Medicine
DUNS #
069687242
City
Tampa
State
FL
Country
United States
Zip Code
33612