Project Start
1989-05-01
Project End
Budget Start
1988-11-01
Budget End
1989-10-31
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Zydowsky, L D; Etzkorn, F A; Chang, H Y et al. (1992) Active site mutants of human cyclophilin A separate peptidyl-prolyl isomerase activity from cyclosporin A binding and calcineurin inhibition. Protein Sci 1:1092-9
Swanson, S K; Born, T; Zydowsky, L D et al. (1992) Cyclosporin-mediated inhibition of bovine calcineurin by cyclophilins A and B. Proc Natl Acad Sci U S A 89:3741-5
Walsh, C T; Zydowsky, L D; McKeon, F D (1992) Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 267:13115-8
Zydowsky, L D; Ho, S I; Baker, C H et al. (1992) Overexpression, purification, and characterization of yeast cyclophilins A and B. Protein Sci 1:961-9
Neri, P; Gemmecker, G; Zydowsky, L D et al. (1991) NMR studies of [U-13C]cyclosporin A bound to human cyclophilin B. FEBS Lett 290:195-9
Price, E R; Zydowsky, L D; Jin, M J et al. (1991) Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence. Proc Natl Acad Sci U S A 88:1903-7
Ke, H M; Zydowsky, L D; Liu, J et al. (1991) Crystal structure of recombinant human T-cell cyclophilin A at 2.5 A resolution. Proc Natl Acad Sci U S A 88:9483-7