Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32ES005701-03
Application #
2872271
Study Section
Special Emphasis Panel (ZRG4-ALTX-1)
Project Start
1999-02-01
Project End
Budget Start
1999-02-01
Budget End
1999-07-12
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Other Basic Sciences
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Wang, X; Santostefano, M J; DeVito, M J et al. (2000) Extrapolation of a PBPK model for dioxins across dosage regimen, gender, strain, and species. Toxicol Sci 56:49-60
Santostefano, M J; Richardson, V M; Walker, N J et al. (1999) Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. Toxicol Sci 52:9-19
Richardson, V M; Santostefano, M J; Birnbaum, L S (1998) Daily cycle of bHLH-PAS proteins, Ah receptor and Arnt, in multiple tissues of female Sprague-Dawley rats. Biochem Biophys Res Commun 252:225-31
Pollenz, R S; Santostefano, M J; Klett, E et al. (1998) Female Sprague-Dawley rats exposed to a single oral dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibit sustained depletion of aryl hydrocarbon receptor protein in liver, spleen, thymus, and lung. Toxicol Sci 42:117-28
Santostefano, M J; Wang, X; Richardson, V M et al. (1998) A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose- and time-dependent effects. Toxicol Appl Pharmacol 151:294-310