Abstract

In the ground squirrel there are three anatomically distinct types of OFF-bipolar cells, which each using a different type of AMPA or kainate receptor to receive cone signals. Due to differences in receptor kinetics, each OFF-bipolar cell type carries a different temporal signal to inner retina. The different glutamate receptors also offer the possibility for distinct actions of modulators such as dopamine.
Specific aims 1 and 2 test whether dopamine modulates transmission at the cone to OFF-bipolar cell synapse, whether modulation differs among OFF-bipolar cell types, and what type of intracellular cascades are involved.
Specific aim 3 tests whether modulation by dopamine has a functional role in slow contrast adaptation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32EY015967-01
Application #
6834992
Study Section
Special Emphasis Panel (ZRG1-F02B (20))
Program Officer
Mariani, Andrew P
Project Start
2005-01-15
Project End
2008-01-14
Budget Start
2005-01-15
Budget End
2006-01-14
Support Year
1
Fiscal Year
2004
Total Cost
$42,976
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611