The input-output function of a neuron is defined by the combined expression of synaptic and intrinsic properties. These properties are not static and many forms of plasticity involve coordinated changes in both synaptic strength and intrinsic excitability. However, the way in which a neuron co-regulates these properties is not well-understood. This project aims to define the underlying relationship between a neuron's intrinsic and synaptic properties, focusing on the retino-tectal circuit of the tadpole, where postsynaptic tectal neurons receive direct input from retinal ganglion cells. A series of whole-cell electrophysiological recordings will be carried put in order to characterize the relationship between intrinsic and synaptic properties expressed in individual neurons.
Aim 1 characterizes how synaptic and intrinsic properties of the tectal neurons change throughout development of the retino-tectal circuit.
Aim 2 explores how specifically altering either an intrinsic or synaptic property during development may alter (1) the input-output function of the neuron, (2) circuit formation.
Aim 3 addresses how modulation may regulate intrinsic and synaptic properties and, ultimately, circuit function. Dysregulation of these processes may ultimately lead to pathological states such as epilepsy. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32EY016939-01A1
Application #
7111420
Study Section
Special Emphasis Panel (ZRG1-F03B-G (20))
Program Officer
Oberdorfer, Michael
Project Start
2006-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
1
Fiscal Year
2006
Total Cost
$48,796
Indirect Cost
Name
Brown University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912