This project takes advantage of a well-characterized oculomotor behavior and its easily-accessed neural substrate in the goldfish as a model for a distinct neural computation, the integration of velocity over time. The velocity-storage integrator in Area II of the goldfish brain will be approached using in vitro and in vivo techniques to elucidate the relationship between structure, function, and plasticity, and to test the hypothesis that neural integration relies on the intrinsic membrane properties of integrator neurons as well as their network connectivity. Area II neurons will be characterized by their morphology and intrinsic membrane properties and assayed alternately within and separated from their functional networks for integrative characteristics. A training paradigm will be used to specify the interaction of integrator function with motor learning, and the role of integrator neurons in learning will be assessed by recording from their targets in the oculomotor learning network, vestibulocerebellar purkinje cells. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32EY017510-01
Application #
7112639
Study Section
Special Emphasis Panel (ZRG1-F02B-B (20))
Program Officer
Hunter, Chyren
Project Start
2006-04-10
Project End
2009-04-09
Budget Start
2006-04-10
Budget End
2007-04-09
Support Year
1
Fiscal Year
2006
Total Cost
$45,976
Indirect Cost
Name
New York University
Department
Physiology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016