Analysis of Beta-Adrenergic Receptor Desensitization

Hausdorff, William P.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 5F32GM013182-02
• Application #: 3044237
• Study Section: Special Emphasis Panel (BI)
• Project Start: 1990-05-01
• Budget Start: 1990-05-01
• Budget End: 1990-12-31
• Support Year: 2
• Fiscal Year: 1990

Institution

• Name: Duke University
• Type: Schools of Medicine
• DUNS #: 071723621
• City: Durham
• State: NC
• Country: United States
• Zip Code: 27705

Publications

Mueller, J P; Bukusoglu, G; Sonenshein, A L (1992) Transcriptional regulation of Bacillus subtilis glucose starvation-inducible genes: control of gsiA by the ComP-ComA signal transduction system. J Bacteriol 174:4361-73

Campbell, P T; Hnatowich, M; O'Dowd, B F et al. (1991) Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration. Mol Pharmacol 39:192-8

Hausdorff, W P; Campbell, P T; Ostrowski, J et al. (1991) A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. Proc Natl Acad Sci U S A 88:2979-83

Hausdorff, W P; Lohse, M J; Bouvier, M et al. (1990) Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symp Soc Exp Biol 44:225-40

Hausdorff, W P; Hnatowich, M; O'Dowd, B F et al. (1990) A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of J Biol Chem 265:1388-93

Hausdorff, W P; Caron, M G; Lefkowitz, R J (1990) Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J 4:2881-9