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Tsu, C A; Perona, J J; Fletterick, R J et al. (1997) Structural basis for the broad substrate specificity of fiddler crab collagenolytic serine protease 1. Biochemistry 36:5393-401
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Perona, J J; Tsu, C A; Craik, C S et al. (1997) Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix. Biochemistry 36:5381-92
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Perona, J J; Craik, C S (1995) Structural basis of substrate specificity in the serine proteases. Protein Sci 4:337-60
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Willett, W S; Gillmor, S A; Perona, J J et al. (1995) Engineered metal regulation of trypsin specificity. Biochemistry 34:2172-80
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Perona, J J; Hedstrom, L; Rutter, W J et al. (1995) Structural origins of substrate discrimination in trypsin and chymotrypsin. Biochemistry 34:1489-99
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Tsu, C A; Perona, J J; Schellenberger, V et al. (1994) The substrate specificity of Uca pugilator collagenolytic serine protease 1 correlates with the bovine type I collagen cleavage sites. J Biol Chem 269:19565-72
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Perona, J J; Hedstrom, L; Wagner, R L et al. (1994) Exogenous acetate reconstitutes the enzymatic activity of trypsin Asp189Ser. Biochemistry 33:3252-9
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Hedstrom, L; Perona, J J; Rutter, W J (1994) Converting trypsin to chymotrypsin: residue 172 is a substrate specificity determinant. Biochemistry 33:8757-63
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Perona, J J; Tsu, C A; McGrath, M E et al. (1993) Relocating a negative charge in the binding pocket of trypsin. J Mol Biol 230:934-49
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Perona, J J; Craik, C S; Fletterick, R J (1993) Locating the catalytic water molecule in serine proteases. Science 261:620-2
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