Regulation of Phospholipase C by G-Proteins

Smrcka, Alan V.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 5F32GM014489-02
• Application #: 3046056
• Study Section: Biological Sciences 2 (BIOL)
• Project Start: 1992-05-01
• Budget Start: 1992-05-01
• Budget End: 1993-04-30
• Support Year: 2
• Fiscal Year: 1992

Institution

• Name: University of Texas Sw Medical Center Dallas
• Type: Schools of Medicine
• City: Dallas
• State: TX
• Country: United States
• Zip Code: 75390

Publications

Sternweis, P C; Smrcka, A V (1993) G proteins in signal transduction: the regulation of phospholipase C. Ciba Found Symp 176:96-106;discussion 106-11

Smrcka, A V; Sternweis, P C (1993) Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C beta by G protein alpha and beta gamma subunits. J Biol Chem 268:9667-74

Ross, E M; Berstein, G (1993) Regulation of the M1 muscarinic receptor-Gq-phospholipase C-beta pathway by nucleotide exchange and GTP hydrolysis. Life Sci 52:413-9

Berstein, G; Blank, J L; Smrcka, A V et al. (1992) Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. J Biol Chem 267:8081-8

Sternweis, P C; Smrcka, A V; Gutowski, S (1992) Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq. Philos Trans R Soc Lond B Biol Sci 336:35-41;discussion 41-2