Engineering an Active Site in A Protein Core

Wray, Jonathan W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of General Medical Sciences (NIGMS)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 1F32GM017434-01
• Application #: 2172384
• Study Section: Special Emphasis Panel (ZRG3-BIOM (01))
• Project Start: 1995-10-04
• Budget Start: 1995-05-01
• Budget End: 1996-04-30
• Support Year: 1
• Fiscal Year: 1995

Institution

• Name: University of Oregon
• Department: Biochemistry
• Type: Schools of Arts and Sciences
• DUNS #: 948117312
• City: Eugene
• State: OR
• Country: United States
• Zip Code: 97403

Publications

Wray, J W; Baase, W A; Ostheimer, G J et al. (2000) Use of a non-rigid region in T4 lysozyme to design an adaptable metal-binding site. Protein Eng 13:313-21

Wray, J W; Baase, W A; Lindstrom, J D et al. (1999) Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability. J Mol Biol 292:1111-20