This proposal aims to investigate the regulation of septum formation in Bacillus subtilis. Many of the components of this process have been identified, but recently, investigation of a sigma H mutant pointed towards a heretofore unidentified regulatory factor. Initially, the defect in the sigma H mutant will be further investigated. Subsequently, through the use of two independent genetic screens and a database search, the sigma H-dependent regulatory factor will be identified. A better understanding of the regulation of septum formation and cell division can help identify new drug targets and ultimately lead to insight into uncontrolled cell proliferation in eukaryotic cells, i.e. cancer.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM020165-02
Application #
6315527
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Program Officer
Wolfe, Paul B
Project Start
1999-09-20
Project End
Budget Start
2000-09-20
Budget End
2001-09-19
Support Year
2
Fiscal Year
2000
Total Cost
$37,516
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138