The development of new and highly enantioselective processes has become a major focus of synthetic organic chemistry. Such processes can allow for the more rapid and efficient preparation of medicines, and thus impact the health care industry. This application will address previously unexplored aspects of a chemical process for the establishment of quaternary carbon stereocenters (carbon atoms with four different non hydrogen groups attached). With the knowledge gained from this initial study, an attempt will be made to improve known catalytic methods. Potential applications include a general route to cyclopentanones (five membered ring ketones) containing quaternary centers, and the total synthesis of a family of natural products, the Dolabellanes. This particular family of natural products exhibit potent antibiotic activities, as well as anticancer activity and a significant influence on blood pressure in mammals.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM064195-02
Application #
6526253
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Marino, Pamela
Project Start
2002-09-01
Project End
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
2
Fiscal Year
2002
Total Cost
$38,320
Indirect Cost
Name
Harvard University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138