The total synthesis of the polypyrrolindoindoline alkaloid quadrigemine H is described. The synthetic plan utilizes the intramolecular asymmetric Heck chemistry to construct the four quaternary carbon centers in the molecule. Members of the polypyrrolindoline alkaloids demonstrate a wide range of biological activity, including cytotoxicity, anti-viral, anti- bact3rial, anti-fungal, and anti-canndidal activities. The methodology to be developed can be readily adapted to synthesize the whole family of these alkaloids.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32GM064946-01
Application #
6445275
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Ikeda, Richard A
Project Start
2002-03-18
Project End
Budget Start
2002-03-18
Budget End
2003-03-17
Support Year
1
Fiscal Year
2002
Total Cost
$36,592
Indirect Cost
Name
University of California Irvine
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697