Directed, selective organic chemical reactions in water will lead to more efficient synthesis of medicinal compounds. Such reactions will shorten synthetic routes; lower the cost, hazards, and environmental impact associated with organic solvents at every stage of their use; and make possible transformations unachievable by current synthetic methodology. The ultimate goal of the proposed research is to further develop synthetic organic methodology in aqueous solution. Specifically, control of chemo-, regio-, and stereoselectivity by hydrophobic interactions in aqueous solution will be investigated in two systems: reduction with substituted cyanoborohydrides, and oxidation with dioxiranes derived from hydrophobic ketones. These reagents and the model substrates will be synthesized by established methods; product mixtures will be analyzed by HPLC.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM065752-02
Application #
6626247
Study Section
Special Emphasis Panel (ZRG1-F04 (20))
Program Officer
Ikeda, Richard A
Project Start
2002-02-25
Project End
Budget Start
2003-02-25
Budget End
2004-02-24
Support Year
2
Fiscal Year
2003
Total Cost
$41,608
Indirect Cost
Name
Columbia University (N.Y.)
Department
Chemistry
Type
Other Domestic Higher Education
DUNS #
049179401
City
New York
State
NY
Country
United States
Zip Code
10027