The association between the Hawaiian squid Euprymna scolopes and the bioluminescent bacterium Vibrio fischeri provides a model system to study the signal exchange between a prokaryote and a eukaryote during establishment of symbiosis. The hybrid sensor kinase RscS of V. fischeri is required for the initiation of symbiosis. As part of a two component regulatory system, RscS likely receives a colonization signal and transmits this signal to a response regulator, ultimately resulting in successful colonization of the squid. This work will examine the structure of RscS to determine the region(s) of the protein required for detection of the colonization signal. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32GM073523-03
Application #
7169816
Study Section
Special Emphasis Panel (ZRG1-F08 (20))
Program Officer
Portnoy, Matthew
Project Start
2005-02-01
Project End
2008-01-31
Budget Start
2007-02-01
Budget End
2008-01-31
Support Year
3
Fiscal Year
2007
Total Cost
$50,428
Indirect Cost
Name
Loyola University Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Geszvain, Kati; Visick, Karen L (2008) Multiple factors contribute to keeping levels of the symbiosis regulator RscS low. FEMS Microbiol Lett 285:33-9