This research is aimed at identifying interacting loci that contribute to reproductive isolation between the model plant Physcomitrella patens and its wild relative Physcomitrium pyriforme. A combination of classical genetic and modern genomic approaches will be used to identify genes that fail to interact properly in a hybrid genetic background. Such maladaptive interactions among functional loci may contribute to a wide variety of complex diseases in humans. The P. patens model provides a simple genetic system where the molecular genetics of multilocus interactions can be easily manipulated and studied. The identification of molecular variants underlying complex traits, like reproductive isolation, opens several new avenues of research into the specific mechanisms of adaptation and speciation. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32GM075606-01
Application #
7000090
Study Section
Special Emphasis Panel (ZRG1-F08 (20))
Program Officer
Dearolf, Charles R
Project Start
2005-07-01
Project End
2008-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
1
Fiscal Year
2005
Total Cost
$42,068
Indirect Cost
Name
Washington University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
McDaniel, Stuart F; Neubig, Kurt M; Payton, Adam C et al. (2013) Recent gene-capture on the UV sex chromosomes of the moss Ceratodon purpureus. Evolution 67:2811-22
Perroud, Pierre-Francois; Cove, David J; Quatrano, Ralph S et al. (2011) An experimental method to facilitate the identification of hybrid sporophytes in the moss Physcomitrella patens using fluorescent tagged lines. New Phytol 191:301-6
McDaniel, Stuart F; von Stackelberg, Mark; Richardt, Sandra et al. (2010) The speciation history of the Physcomitrium--Physcomitrella species complex. Evolution 64:217-31
Hoang, Quoc Truong; Cho, Sung Hyun; McDaniel, Stuart F et al. (2009) An actinoporin plays a key role in water stress in the moss Physcomitrella patens. New Phytol 184:502-10
Quatrano, Ralph S; McDaniel, Stuart F; Khandelwal, Abha et al. (2007) Physcomitrella patens: mosses enter the genomic age. Curr Opin Plant Biol 10:182-9