The medial amygdala posterior dorsal (MEApd) and principal nucleus of the bed nucleus of the stria terminalis (BSTpr) are thought to be critical for integrating hormonal and olfactory signals and modulating reproductive behavior accordingly. Our long term goal is to elucidate the connectivity and function of genetically defined MEApd and BSTpr neuronal subpopulations in order to determine the specific circuits and mechanisms responsible for translating hormonal and chemosensory inputs into specific behavioral outputs. The specific hypothesis to be tested in this proposal is that MEApd and BSTpr contain multiple functionally distinct neuronal subpopulations, each of which make essential but unique contributions to reproductive behavior. This hypothesis will be tested via the following three specific aims: 1) Use classical neuroanatomical tracing to determine if multiple neuronal subpopulations with distinct connectivity exist in MEApd and BSTpr; 2) Determine if MEApd receives input from both the AOB and MOB using Cre-dependent transneuronal tracers; 3) Use genetic ablations to test the hypothesis that distinct MEApd and BSTpr neuronal subpopulations serve unique functional roles in modulating male reproductive behavior. ? ? ?

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HD055198-01
Application #
7155754
Study Section
Special Emphasis Panel (ZRG1-F02A-H (20))
Program Officer
Lamar, Charisee A
Project Start
2006-09-18
Project End
2009-09-17
Budget Start
2006-09-18
Budget End
2007-09-17
Support Year
1
Fiscal Year
2006
Total Cost
$50,428
Indirect Cost
Name
California Institute of Technology
Department
Type
Schools of Arts and Sciences
DUNS #
009584210
City
Pasadena
State
CA
Country
United States
Zip Code
91125
Anthony, Todd E; Dee, Nick; Bernard, Amy et al. (2014) Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell 156:522-36
Lee, Hyosang; Kim, Dong-Wook; Remedios, Ryan et al. (2014) Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus. Nature 509:627-32
Anthony, Todd E; Heintz, Nathaniel (2008) Genetic lineage tracing defines distinct neurogenic and gliogenic stages of ventral telencephalic radial glial development. Neural Dev 3:30