The Gla Domain in the Function of Coagulant Proteins

Larson, Peter J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Postdoctoral Individual National Research Service Award (F32)
• Project #: 1F32HL008510-01
• Application #: 3051884
• Study Section: Clinical Trials (CLIN)
• Project Start: 1991-12-20
• Budget Start: 1991-07-01
• Budget End: 1992-07-31
• Support Year: 1
• Fiscal Year: 1991

Institution

• Name: University of North Carolina Chapel Hill
• Type: Schools of Medicine
• DUNS #: 078861598
• City: Chapel Hill
• State: NC
• Country: United States
• Zip Code: 27599

Publications

Whinna, H C; Lesesky, E B; Monroe, D M et al. (2004) Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. J Thromb Haemost 2:1127-34

Larson, P J; Camire, R M; Wong, D et al. (1998) Structure/function analyses of recombinant variants of human factor Xa: factor Xa incorporation into prothrombinase on the thrombin-activated platelet surface is not mimicked by synthetic phospholipid vesicles. Biochemistry 37:5029-38

Larson, P J; Stanfield-Oakley, S A; VanDusen, W J et al. (1996) Structural integrity of the gamma-carboxyglutamic acid domain of human blood coagulation factor IXa Is required for its binding to cofactor VIIIa. J Biol Chem 271:3869-76

Larson, P J; High, K A (1992) Biology of inherited coagulopathies: factor IX. Hematol Oncol Clin North Am 6:999-1009