Aerobic exercise training induces angiogenesis. The mechanisms and physiological signals which trigger exercise-induced angiogenesis are poorly understood. The objective of this study is to elucidate the growth factors responsible for exercise-induced angiogenesis and the pathways through which angiogenesis is initiated. And physiological variable which changes as a result of exercise could potentially trigger angiogenesis. Among the potential initiating signals for exercise-induced angiogenesis are exercise intensity, tissue hypoxia, tissue acid-base status, increases in muscle blood flow, increases in muscle perfusion pressure, nitric oxide, and prostacyclin. In diseases such as renal failure and certain cardiopulmonary diseases, a reduction in the capillary to muscle fiber ratio has been observed. By understanding the mechanisms which trigger exercise-induced angiogenesis, the capillary to muscle fiber ratio could be improved in these patients. Improvements in the capillary to muscle fiber ratio could result in improvements in the conductance of O2 and improve the condition of these patients.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL009624-03
Application #
2771203
Study Section
Special Emphasis Panel (ZRG2-PSF (02))
Project Start
1996-09-01
Project End
Budget Start
1998-09-01
Budget End
1999-08-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gavin, T P; Wagner, P D (2002) Attenuation of the exercise-induced increase in skeletal muscle Flt-1 mRNA by nitric oxide synthase inhibition. Acta Physiol Scand 175:201-9
Brutsaert, Tom D; Gavin, Timothy P; Fu, Zhenxing et al. (2002) Regional differences in expression of VEGF mRNA in rat gastrocnemius following 1 hr exercise or electrical stimulation. BMC Physiol 2:8
Gavin, T P; Wagner, P D (2001) Effect of short-term exercise training on angiogenic growth factor gene responses in rats. J Appl Physiol 90:1219-26
Gavin, T P; Spector, D A; Wagner, H et al. (2000) Effect of captopril on skeletal muscle angiogenic growth factor responses to exercise. J Appl Physiol 88:1690-7
Gavin, T P; Spector, D A; Wagner, H et al. (2000) Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise. J Appl Physiol 88:1192-8
Barker, R C; Hopkins, S R; Kellogg, N et al. (1999) Measurement of cardiac output during exercise by open-circuit acetylene uptake. J Appl Physiol 87:1506-12
Richardson, R S; Grassi, B; Gavin, T P et al. (1999) Evidence of O2 supply-dependent VO2 max in the exercise-trained human quadriceps. J Appl Physiol 86:1048-53