Abstract

This proposal is based on exciting preliminary findings that show attenuation of baroreceptor function in rodents exposed to intermittent hypoxia (IH) during the 1st month of life. IH has been previously shown to induce hypertension similar to that found in sleep-disordered breathing. We hypothesized that the occurrence of IH during a critical period of development would lead to long-lasting alterations in baroreceptor properties that could predispose for the development of hypertension in susceptible individuals. We therefore propose to determine whether (1) lH during prenatal life modifies baroreceptor sensitivity during adulthood; (2) lH during early postnatal life modifies baroreflex sensitivity during adulthood; and (3) lH during early postnatal life leads to accelerated development of systemic hypertension in spontaneously hypertensive rats. These studies have the potential to uncover important mechanisms underlying the emergence of systemic hypertension in genetically susceptible subjects, and will further demonstrate the importance of early developmental antecedents in disease causation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL070494-03
Application #
6744022
Study Section
Special Emphasis Panel (ZRG1-F10 (20))
Program Officer
Rothgeb, Ann E
Project Start
2002-05-01
Project End
2005-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
3
Fiscal Year
2004
Total Cost
$56,536
Indirect Cost

  Institution

Name
University of Louisville
Department
Pediatrics
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292

  Publications

Soukhova-O'Hare, Galia K; Ortines, Roger V; Gu, Yan et al. (2008) Postnatal intermittent hypoxia and developmental programming of hypertension in spontaneously hypertensive rats: the role of reactive oxygen species and L-Ca2+ channels. Hypertension 52:156-62
Soukhova-O'Hare, Galia K; Shah, Zahoor A; Lei, Zhenmin et al. (2008) Erectile dysfunction in a murine model of sleep apnea. Am J Respir Crit Care Med 178:644-50
Soukhova-O'Hare, G K; Schmidt, M H; Nozdrachev, A D et al. (2007) A novel mouse model for assessment of male sexual function. Physiol Behav 91:535-43
Soukhova-O'Hare, Galia K; Cheng, Zixi Jack; Roberts, Andrew M et al. (2006) Postnatal intermittent hypoxia alters baroreflex function in adult rats. Am J Physiol Heart Circ Physiol 290:H1157-64
Soukhova-O'Hare, Galia K; Roberts, Andrew M; Gozal, David (2006) Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats. Neurosci Lett 399:181-5