Understanding the molecular events controlling the development of the embryonic vasculature has the promise of providing a variety of therapeutic tools useful in clinical settings aimed at regulating vessel growth. These opportunities include the repair of damaged vessels in conditions of inflammation, the stimulation of vessel growth following ischaemic injury, and the repression of vasculogenesis/angiogenesis to block the growth of tumors. This proposal aims at understanding the role(s) that two members of the GATA family of transcription factors, GATA4 and -6, play in the development of the embryonic vascular system.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL071450-02
Application #
6744023
Study Section
Special Emphasis Panel (ZRG1-F05 (20))
Program Officer
Commarato, Michael
Project Start
2003-05-01
Project End
2006-02-28
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
2
Fiscal Year
2004
Total Cost
$48,928
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Xin, Mei; Davis, Christopher A; Molkentin, Jeffery D et al. (2006) A threshold of GATA4 and GATA6 expression is required for cardiovascular development. Proc Natl Acad Sci U S A 103:11189-94