The traditional referral guidelines for lung transplant in CF are largely based on a FEV <30% predicted. The optimal timing for referral has not been determined. Other factors may be important in predicting the risk of death in these patients. The presence of emerging infectious CF pathogens may be associated with a higher risk of death. These factors have not been tested in other studies. The identification of the above variables as risk factors for death may be used to modify the referral process or pre-transplantation therapy and improve survival of CF patients awaiting transplantation. We propose to perform a three-center retrospective cohort study, with the following aims: (1) determine the association of emerging CF pathogens (including Aspergillus spp. And MRSA) pretransplant with mortality while awaiting lung transplantation: before and after referral for lung transplantation, (2) determine the association of poor nutritional status (including shorter height) pretransplant with mortality while awaiting lung transplantation (3) determine the association of poor pulmonary function (including % predicted FEV1) pretransplant with mortality while awaiting lung transplantation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32HL074534-01
Application #
6691333
Study Section
Special Emphasis Panel (ZRG1-EDC-3 (01))
Program Officer
Colombini-Hatch, Sandra
Project Start
2003-07-24
Project End
2005-07-23
Budget Start
2003-07-24
Budget End
2004-07-23
Support Year
1
Fiscal Year
2003
Total Cost
$74,880
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Belkin, Richard A; Henig, Noreen R; Singer, Lianne G et al. (2006) Risk factors for death of patients with cystic fibrosis awaiting lung transplantation. Am J Respir Crit Care Med 173:659-66