We propose to perform noninvasive measurements in humans, using established techniques and novel functional magnetic resonance techniques, and combine these experimental approaches with modeling studies to elucidate changes in the heterogeneity of lung mechanics and pulmonary blood flow that occur during the early stages of pulmonary interstitial edema. We will utilize a 30-degree head-down tilt (HOT) to provoke an increase in fluid content of the lung, and consequently the early stages of pulmonary interstitial edema. This model of rapid and acute change in lung fluid balance will provide a means of inducing changes in lung mechanics and the distribution of pulmonary blood flow in the periphery of the lung. We hypothesize that the alteration in the fluid balance of the lung that occurs during 30-degree HOT in humans will increase lung water, heterogeneity of lung tissue compliance in the periphery, airway resistance, and heterogeneity of pulmonary blood flow. This study has relevance for providing (1) a 6as/c understanding of how the early stages of pulmonary interstitial edema affects lung function, and (2) a model that can be used for studies relating to the diagnosis and treatment of subclinical edema. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL078128-03
Application #
7215139
Study Section
Special Emphasis Panel (ZRG1-F10 (20))
Program Officer
Colombini-Hatch, Sandra
Project Start
2005-04-01
Project End
2008-03-31
Budget Start
2007-04-01
Budget End
2008-03-31
Support Year
3
Fiscal Year
2007
Total Cost
$52,048
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hopkins, Susan R; Arai, Tatsuya J; Henderson, A Cortney et al. (2010) Lung volume does not alter the distribution of pulmonary perfusion in dependent lung in supine humans. J Physiol 588:4759-68
Henderson, A Cortney; Prisk, G Kim; Levin, David L et al. (2009) Characterizing pulmonary blood flow distribution measured using arterial spin labeling. NMR Biomed 22:1025-35
Arai, T J; Henderson, A C; Dubowitz, D J et al. (2009) Hypoxic pulmonary vasoconstriction does not contribute to pulmonary blood flow heterogeneity in normoxia in normal supine humans. J Appl Physiol (1985) 106:1057-64
Burnham, K J; Arai, T J; Dubowitz, D J et al. (2009) Pulmonary perfusion heterogeneity is increased by sustained, heavy exercise in humans. J Appl Physiol (1985) 107:1559-68
Prisk, G Kim; Yamada, Kei; Henderson, A Cortney et al. (2007) Pulmonary perfusion in the prone and supine postures in the normal human lung. J Appl Physiol 103:883-94
Hopkins, Susan R; Henderson, A Cortney; Levin, David L et al. (2007) Vertical gradients in regional lung density and perfusion in the supine human lung: the Slinky effect. J Appl Physiol 103:240-8
Henderson, A Cortney; Levin, David L; Hopkins, Susan R et al. (2006) Steep head-down tilt has persisting effects on the distribution of pulmonary blood flow. J Appl Physiol 101:583-9