A crucial outcome measurement of surgical treatments of atrial fibrillation (AF) such as the Maze and Radial procedures is the preservation of normal atrial function. However, knowledge of normal and abnormal atrial function is sparse, and the techniques to accurately characterize atrial function and its complex three-dimensional nature are limited. This lack of a reliable method to characterize atrial function has limited both experimental and clinical evaluation of the physiological consequences of the surgical treatment of AF. Recently, cardiac magnetic resonance imaging (CMR) has for the first time allowed for the accurate quantification of atrial function. Previous studies have demonstrated reduced atrial function with the Maze procedure and greater preservation of atrial function with the Radial procedure to ablate AF. However, cardiac echocardiography was used to make these assessments. There have been no studies on the effect of the multiple incisions of these procedures on regional wall motion or overall atrial ejection due to limitations of echocardiography. With CMR, the physiological and functional consequences of surgical treatment will be examined. This will allow the development of less invasive surgical techniques to treat AF.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL082129-02
Application #
7105434
Study Section
Special Emphasis Panel (ZRG1-DIG-B (21))
Program Officer
Meadows, Tawanna
Project Start
2005-07-14
Project End
2007-07-13
Budget Start
2006-07-14
Budget End
2007-07-13
Support Year
2
Fiscal Year
2006
Total Cost
$50,428
Indirect Cost
Name
Washington University
Department
Surgery
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Saint, Lindsey L; Damiano Jr, Ralph J; Cuculich, Phillip S et al. (2013) Incremental risk of the Cox-maze IV procedure for patients with atrial fibrillation undergoing mitral valve surgery. J Thorac Cardiovasc Surg 146:1072-7
Saint, Lindsey L; Bailey, Marci S; Prasad, Sunil et al. (2012) Cox-Maze IV results for patients with lone atrial fibrillation versus concomitant mitral disease. Ann Thorac Surg 93:789-94; discussion 794-5
Damiano Jr, Ralph J; Schwartz, Forrest H; Bailey, Marci S et al. (2011) The Cox maze IV procedure: predictors of late recurrence. J Thorac Cardiovasc Surg 141:113-21
Voeller, Rochus K; Zierer, Andreas; Lall, Shelly C et al. (2010) Efficacy of a novel bipolar radiofrequency ablation device on the beating heart for atrial fibrillation ablation: a long-term porcine study. J Thorac Cardiovasc Surg 140:203-8
Voeller, Rochus K; Zierer, Andreas; Lall, Shelly C et al. (2008) The effects of the Cox maze procedure on atrial function. J Thorac Cardiovasc Surg 136:1257-64, 1264.e1-3
Sakamoto, Shun-ichiro; Voeller, Rochus K; Melby, Spencer J et al. (2008) Surgical ablation for atrial fibrillation: the efficacy of a novel bipolar pen device in the cardioplegically arrested and beating heart. J Thorac Cardiovasc Surg 136:1295-301
Voeller, Rochus K; Bailey, Marci S; Zierer, Andreas et al. (2008) Isolating the entire posterior left atrium improves surgical outcomes after the Cox maze procedure. J Thorac Cardiovasc Surg 135:870-7
Damiano Jr, Ralph J; Schuessler, Richard B; Voeller, Rochus K (2007) Surgical treatment of atrial fibrillation: a look into the future. Semin Thorac Cardiovasc Surg 19:39-45