There are conflicting reports regarding the adverse effects of VITAMIN D (Vit D) deficiency on several major chronic diseases, such as CORONARY HEART DISEASE (CHD) and CANCER. It is reported that HYPO- VITAMINOSIS D is widespread, the ELDERLY being particularly susceptible. The main source of Vit D in North America is through SUNLIGHT EXPOSURE. The emphasis placed on protection from sunlight exposure to reduce skin CANCER risk may be creating an increased risk for CHD. By using the Adventist Health Study-2 Questionnaire data and itsl00,000 subjects countrywide, we intend to further elucidate the relationships between serum 25 hydroxy Vit D(25-OH-D) (the best indicator of Vit D status) and FATAL CHD and TOTAL MORTALITY after 5 years follow-up. We will use blood samples collected for the calibration study to determine actual serum Vit D levels. REGRESSION CALIBRATION will then be used to predict expected values of serum 25 hydroxy Vit D conditonal on exposures to DIETARY VIT D, CALCIUM INTAKE, SUNLIGHT, and AGE. Results for BLACKS will be compared to those of """"""""Whites"""""""" because SKIN PIGMENTATION reduces the amount of the active form of Vit D converted from precursors.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL082435-02
Application #
7207941
Study Section
Epidemiology of Chronic Diseases Study Section (ECD)
Program Officer
Aviles-Santa, Larissa
Project Start
2005-08-15
Project End
2008-11-30
Budget Start
2006-12-01
Budget End
2007-11-30
Support Year
2
Fiscal Year
2007
Total Cost
$58,340
Indirect Cost
Name
Loma Linda University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
009656273
City
Loma Linda
State
CA
Country
United States
Zip Code
92350
Chan, Jacqueline; Jaceldo-Siegl, Karen; Fraser, Gary E (2010) Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites. Cancer Causes Control 21:501-11
Chan, Jacqueline; Jaceldo-Siegl, Karen; Fraser, Gary E (2009) Serum 25-hydroxyvitamin D status of vegetarians, partial vegetarians, and nonvegetarians: the Adventist Health Study-2. Am J Clin Nutr 89:1686S-1692S