Abstract

The prevalence of obesity in children and adolescents is increasing at an alarming rate. Evidence exists that childhood obesity is associated with an increased risk of morbidity and mortality through adulthood. The US population has moved towards a sedentary life style, which has further exacerbated the obesity epidemic. Central body fat deposition has emerged as an important predictor of the health hazards of obesity. Increased levels of cortisol cause central fat deposition characteristic of the metabolic syndrome. The function of the hypothalamic-pituitary-adrenal axis in obesity has been studied in adults. The correlation between cortisol and the cardiovascular disease risk profile in adolescents is not well established, particularly as related to obesity. Native Americans have a higher incidence of obesity and cardiovascular disease. In this study, we will determine correlates of salivary cortisol in adolescents living in Anadarko, a central location of the Seven Tribes of Southwest Oklahoma. We will also examine the effect of a 12-week standardized exercise training program on salivary cortisol and the cardiovascular disease risk profile in at risk adolescents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32HL083689-04
Application #
7791432
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Meadows, Tawanna
Project Start
2006-09-04
Project End
2010-06-30
Budget Start
2009-09-04
Budget End
2010-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$50,380
Indirect Cost

  Institution

Name
University of Oklahoma Health Sciences Center
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
878648294
City
Oklahoma City
State
OK
Country
United States
Zip Code
73117

  Publications

Roche, Daniel J O; King, Andrea C; Cohoon, Andrew J et al. (2013) Hormonal contraceptive use diminishes salivary cortisol response to psychosocial stress and naltrexone in healthy women. Pharmacol Biochem Behav 109:84-90
Lovallo, William R; Farag, Noha H; Sorocco, Kristen H et al. (2013) Early life adversity contributes to impaired cognition and impulsive behavior: studies from the Oklahoma Family Health Patterns Project. Alcohol Clin Exp Res 37:616-23
Lovallo, William R; King, Andrea C; Farag, Noha H et al. (2012) Naltrexone effects on cortisol secretion in women and men in relation to a family history of alcoholism: studies from the Oklahoma Family Health Patterns Project. Psychoneuroendocrinology 37:1922-8
Farag, Noha H; Moore, William E; Thompson, David M et al. (2010) Evaluation of a community-based participatory physical activity promotion project: effect on cardiovascular disease risk profiles of school employees. BMC Public Health 10:313