Abstract

The proposed research will utilize behavioral and molecular genetic techniques to examine the etiology of DSM-IV Attention Deficit/Hyperactivity Disorder (ADHD) in a sample of 100 8-13 year old twins selected because at least one twin meets the criteria for ADHD. Univariate behavioral genetic models will be utilized to estimate the genetic and environmental components of the etiology of the subtypes of ADHD. In addition, bivariate behavior genetic analyses will be utilized to directly examine the influence of common genes on the three proposed subtypes and the etiology of any observed psychiatric comorbidity with ADHD. DNA samples will be obtained from all DZ twins and their families. Association analyses such as the Transmission Disequilibrium Test will be utilized to test whether any component of the ADHD phenotype is significantly associated with any of several theoretically plausible candidate genes. In addition, a bivariate interval mapping linkage analysis will be utilized in a sample of individuals already typed for the relevant markers to test whether a previously mapped quantitative trait locus for reading disability on chromosome 6 is also etiologically related to ADHD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH012100-03
Application #
6185126
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Program Officer
Altman, Fred
Project Start
2000-09-01
Project End
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
3
Fiscal Year
2000
Total Cost
$37,516
Indirect Cost

  Institution

Name
University of Colorado at Boulder
Department
Genetics
Type
Other Domestic Higher Education
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309

  Publications

Rhee, Soo Hyun; Willcutt, Erik G; Hartman, Christie A et al. (2008) Test of alternative hypotheses explaining the comorbidity between attention-deficit/hyperactivity disorder and conduct disorder. J Abnorm Child Psychol 36:29-40
Willcutt, Erik G; Pennington, Bruce F; Olson, Richard K et al. (2007) Understanding comorbidity: a twin study of reading disability and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 144B:709-14
Willcutt, Erik G; Pennington, Bruce F; Olson, Richard K et al. (2005) Neuropsychological analyses of comorbidity between reading disability and attention deficit hyperactivity disorder: in search of the common deficit. Dev Neuropsychol 27:35-78
Hartman, Christie A; Willcutt, Erik G; Rhee, Soo Hyun et al. (2004) The relation between sluggish cognitive tempo and DSM-IV ADHD. J Abnorm Child Psychol 32:491-503
Friedman, Melanie C; Chhabildas, Nomita; Budhiraja, Nisha et al. (2003) Etiology of the comorbidity between RD and ADHD: exploration of the non-random mating hypothesis. Am J Med Genet B Neuropsychiatr Genet 120B:109-15
Willcutt, Erik G; Pennington, Bruce F; Smith, Shelley D et al. (2002) Quantitative trait locus for reading disability on chromosome 6p is pleiotropic for attention-deficit/hyperactivity disorder. Am J Med Genet 114:260-8
Chhabildas, N; Pennington, B F; Willcutt, E G (2001) A comparison of the neuropsychological profiles of the DSM-IV subtypes of ADHD. J Abnorm Child Psychol 29:529-40
Willcutt, E G; Pennington, B F; Boada, R et al. (2001) A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder. J Abnorm Psychol 110:157-72
Willcutt, E G; Pennington, B F (2000) Psychiatric comorbidity in children and adolescents with reading disability. J Child Psychol Psychiatry 41:1039-48
Willcutt, E G; Pennington, B F (2000) Comorbidity of reading disability and attention-deficit/hyperactivity disorder: differences by gender and subtype. J Learn Disabil 33:179-91

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