Because dendrite development has not yet been extensively studied, a number of fundamental questions about dendrite development still need to be answered. The studies described below will focus on the following two questions: (1) What factors control the distinct morphology of a given class of dendrites? (2) Do distinct factors or signal transduction pathways regulate different aspects of dendrite development? Since transcription factors are likely regulators of multiple aspects of dendrite development and the Drosophila PNS is an attractive model system for genetic analysis of dendrite development I will study transcriptional regulation of dendrite development using Drosophila as a model system. Importantly, the Drosophila PNS is composed of multiple classes of neurons with distinct characteristic dendritic branching patterns so these studies should facilitate identification of factors which specify dendrite development in a cell type-specific fashion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32MH071101-02
Application #
6892306
Study Section
Special Emphasis Panel (ZRG1-F03A (20))
Program Officer
Curvey, Mary F
Project Start
2004-05-01
Project End
2006-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
2
Fiscal Year
2005
Total Cost
$48,296
Indirect Cost
Name
University of California San Francisco
Department
Physiology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143