Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
2F32NS009436-03
Application #
2261228
Study Section
Special Emphasis Panel (ZRG1-NEUA (02))
Program Officer
Baughman, Robert W
Project Start
1995-04-01
Project End
1996-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Psychiatry
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Burstein, E S; Spalding, T A; Brann, M R (1998) Structure/function relationships of a G-protein coupling pocket formed by the third intracellular loop of the m5 muscarinic receptor. Biochemistry 37:4052-8
Burstein, E S; Brauner-Osborne, H; Spalding, T A et al. (1997) Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals. J Neurochem 68:525-33
Burstein, E S; Spalding, T A; Brann, M R (1997) Pharmacology of muscarinic receptor subtypes constitutively activated by G proteins. Mol Pharmacol 51:312-9
Burstein, E S; Spalding, T A; Brann, M R (1996) Constitutive activation of chimeric m2/m5 muscarinic receptors and delineation of G-protein coupling selectivity domains. Biochem Pharmacol 51:539-44
Burstein, E S; Spalding, T A; Hill-Eubanks, D et al. (1995) Structure-function of muscarinic receptor coupling to G proteins. Random saturation mutagenesis identifies a critical determinant of receptor affinity for G proteins. J Biol Chem 270:3141-6
Spalding, T A; Burstein, E S; Brauner-Osborne, H et al. (1995) Pharmacology of a constitutively active muscarinic receptor generated by random mutagenesis. J Pharmacol Exp Ther 275:1274-9