Abstract

The proposed research will contribute to our understanding of growth cone mobility, and are well described and focused. The first objective of this proposal is to examine whether inhibition of myosin Ibeta using the CALI technique alters Myosin II atpase activity and mobility. The experiments are straight forward and important. The second observation will use the same micro-CALI techniques used to successfully investigate the roles of myosin V and myosin 1beta in filopodia. These experiments are important, and well described.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
2F32NS009982-03
Application #
2522680
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Nichols, Paul L
Project Start
1998-03-01
Project End
Budget Start
1997-09-12
Budget End
1998-09-11
Support Year
3
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138

  Publications

Svec, Jirí; Ergang, Peter; Mandys, Václav et al. (2010) Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models. Int J Exp Pathol 91:44-53