The overall goal of this proposal is the biochemical and functional characterization of a novel neuronal protein, milton, identified in a genetic screen. Previous experiments showed that milton is necessary for normal synaptic transmission, is localized at synapses, and copurifes with kinesin heavy chain (KHC).
The specific aims of this proposal are: (1) to examine the binding of milton to KHC, (2) to identify additional molecules that bind to milton, and (3) to ascertain the role of milton in synaptic structure and function. Elucidating the role of milton in neuronal function will help us better understand the molecular mechanisms underlying synaptic transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS041735-02
Application #
6699878
Study Section
Special Emphasis Panel (ZRG1-MDCN-1 (01))
Program Officer
Talley, Edmund M
Project Start
2001-06-01
Project End
Budget Start
2002-06-01
Budget End
2003-05-31
Support Year
2
Fiscal Year
2003
Total Cost
$46,192
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115