Abstract

The body of work proposed n this fellowship is aimed at gaining a greater understanding of mamalian forebrain development. In particular, the role of the secreted signaling molecule Sonic Hedgehog in early forebrain patterning will be explored. In the first specific aim, the Sonic Hedgehog signaling pathway will be studied to determine if secondary signaling pathways are activated simultaneously. The second specific aim will address the role of Sonic Hedgehog in early ( The third aim will examine the possible involvement of other signaling pathways in determining the outcome of Sonic Hedgehog signaling. This work will hopefully lead to a deeper understanding of regional specification in the developing forebrain.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
5F32NS042525-03
Application #
6704173
Study Section
Special Emphasis Panel (ZRG1-MDCN-6 (01))
Program Officer
Finkelstein, Robert
Project Start
2002-09-01
Project End
2004-08-31
Budget Start
2003-09-01
Budget End
2004-08-31
Support Year
3
Fiscal Year
2004
Total Cost
$56,308
Indirect Cost

  Institution

Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016

  Publications

Machold, Robert P; Kittell, Deborah Jones; Fishell, Gordon J (2007) Antagonism between Notch and bone morphogenetic protein receptor signaling regulates neurogenesis in the cerebellar rhombic lip. Neural Dev 2:5
Machold, Robert; Hayashi, Shigemi; Rutlin, Michael et al. (2003) Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39:937-50
Rallu, Murielle; Machold, Robert; Gaiano, Nicholas et al. (2002) Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 129:4963-74