The purpose of the nervous system is to generate behavior appropriate to a situation. However, even when the nervous system can produce a very precise behavior, it is not clear how finely each neuron in the system must be tuned to generate that behavior. I propose to study this question by characterizing the intrinsic properties in a single neuron in the crustacean pyloric network. I will do this by delivering semi-realistic inputs to the cell and monitoring the cell's responses. I will relate these properties to the emergent properties at the network level, and the maximal conductances of the cell's voltage-gated channels. The intrinsic properties and emergent properties of the network will be characterized using intracellular and extracellular recording techniques, and they will be related to the voltage-gated conductances using biophysically realistic models of the cell. This work will provide important insights about how nervous systems regulate themselves to maintain proper function.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Postdoctoral Individual National Research Service Award (F32)
Project #
1F32NS050928-01
Application #
6886605
Study Section
Special Emphasis Panel (ZRG1-F02B (20))
Program Officer
Chen, Daofen
Project Start
2004-12-06
Project End
2006-12-05
Budget Start
2004-12-06
Budget End
2005-12-05
Support Year
1
Fiscal Year
2005
Total Cost
$48,296
Indirect Cost
Name
Brandeis University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
616845814
City
Waltham
State
MA
Country
United States
Zip Code
02454
Goaillard, Jean-Marc; Taylor, Adam L; Pulver, Stefan R et al. (2010) Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism. J Neurosci 30:4687-92
Goaillard, Jean-Marc; Taylor, Adam L; Schulz, David J et al. (2009) Functional consequences of animal-to-animal variation in circuit parameters. Nat Neurosci 12:1424-30
Golowasch, Jorge; Thomas, Gladis; Taylor, Adam L et al. (2009) Membrane capacitance measurements revisited: dependence of capacitance value on measurement method in nonisopotential neurons. J Neurophysiol 102:2161-75
Taylor, Adam L; Goaillard, Jean-Marc; Marder, Eve (2009) How multiple conductances determine electrophysiological properties in a multicompartment model. J Neurosci 29:5573-86
Rehm, Kristina J; Taylor, Adam L; Pulver, Stefan R et al. (2008) Spectral analyses reveal the presence of adult-like activity in the embryonic stomatogastric motor patterns of the lobster, Homarus americanus. J Neurophysiol 99:3104-22
Bucher, Dirk; Taylor, Adam L; Marder, Eve (2006) Central pattern generating neurons simultaneously express fast and slow rhythmic activities in the stomatogastric ganglion. J Neurophysiol 95:3617-32
Taylor, Adam L; Hickey, Timothy J; Prinz, Astrid A et al. (2006) Structure and visualization of high-dimensional conductance spaces. J Neurophysiol 96:891-905
Marder, Eve; Bucher, Dirk; Schulz, David J et al. (2005) Invertebrate central pattern generation moves along. Curr Biol 15:R685-99